Gawwwd how I hate taking prednisone, but as usually happens when I get a bad cold, I have a heck of a time breathing which inevitably requires a visit the Dr. to get my life saving med. If taken for a short time it is a miracle drug, but for people who have to take it long term, it's nasty stuff.
Prednisone is particularly effective as an immunosuppressant, and affects virtually all of the 
immune system. It can, therefore, be used in
autoimmune diseases, inflammatory diseases (such as severe
asthma, severe
allergies, Angioedema episodes, severe
poison ivy dermatitis,
systemic lupus erythematosus,
ulcerative colitis,
rheumatoid arthritis,
Bell's Palsy,
Crohn's disease,
pemphigus and
sarcoidosis),
uveitis, various kidney diseases including
nephrotic syndrome,
mononucleosis [Epstein Barr virus], and to prevent and treat
rejection in
organ transplantation. This medicine may also reduce the sex drive. Prednisone has also been used in the treatment of migraine headaches and
cluster headaches and for severe
Aphthous ulcer ("Cankersore") outbreaks.
Prednisone is used as an
antitumor drug. Prednisone is very important in the treatment of
acute lymphoblastic leukemia,
Non-Hodgkin's lymphomas,
multiple myeloma, and other tumors in combination with other anticancer drugs.
Furthermore, the pharmaceutical industry uses prednisone tablets for the calibration of dissolution testing equipment according to the
United States Pharmacopeia (USP).
Intravenous application may be employed for cerebral inflammation, as in the periodic attacks caused by
multiple sclerosis.
Prednisone is also used for the treatment of the Jarisch-Herxheimer Reaction which is common during the treatment of syphilis, and to delay the onset of symptoms of
Duchenne muscular dystrophy. The mechanism for the delay of symptoms is unknown.
Side effects....
Short-term side-effects, as with all glucocorticoids, include high blood
glucose levels, especially in patients that already have
diabetes mellitus or are on other medications that increase blood glucose (such as
tacrolimus), and
mineralocorticoid effects such as fluid retention (it is worth noting, however, that the mineralocorticoid effects of prednisone are very minor; this is why it is not used in the management of adrenal insufficiency unless a more potent mineralocorticoid is administered concomitantly). Additional short-term side-effects include
insomnia,
euphoria, and, rarely,
mania. Long-term side-effects include
Cushing's syndrome, truncal weight gain,
osteoporosis,
glaucoma, type II
diabetes mellitus, and
depression upon withdrawal.